Chang lab @ Penn

Welcome to

CHANG LAB

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RESEARCH INTERESTS

Structures of biological molecules determine their functions. The Chang lab is devoted in understanding biology from structural perspective. Distinct from most of the other structural biology groups working with purified molecules, the Chang lab utilizes Electron Cryotomography, an emerging powerful cryo-electron microscopy imaging technique, to study the structure and mechanism of macromolecular nanomachines directly inside cells. In the native cellular environment, not only the most native conformations and assemblies of the nanomachines can be captured as they are conducting functions, but also their distribution, orientations and interactions to other cellular components can be revealed – enabling the studies of Structural Cell Biology and Molecular Sociology.    

 
 
 
 
 
 
 

Structural cell biology through cryo-electron tomography

 
 
 
 
 
 
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Resolve molecular structures in situ

 
 
 
 
 
 
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Structure and function of complex molecular machines

 
 
 
 
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Host-pathogen interactions

 
 
 
 
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Methods development-

Correlated super-resolution light and electron microscopy

 
 
 
 
 
 
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It is very easy to answer many ... fundamental biological questions; you just look at the thing!
— Richard Feynman (1918-1988)