Chang lab @ Penn

Welcome to

CHANG LAB

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RESEARCH INTERESTS

Structure of macromolecule determines function. The Chang lab is deeply interested and devoted in understanding biology from structural perspective. Distinct from most of the other structural biology groups working with purified macromolecules, the Chang lab utilizes Electron Cryotomography (A.K.A. cryo-electron tomography), an emerging powerful cryo-electron microscopy imaging technique, to study the structure and mechanism of macromolecular nanomachines directly inside cells. In the native cellular environment, electron cryotomography reveals not only native conformations and assemblies of the nanomachines as they are conducting functions, but also their distribution, orientations and interactions to other cellular components – thus enabling studies of Structural Cell Biology and Molecular Sociology.  

 
 
 
 
 
 
 

Structural cell biology through electron cryotomography

 
 
 
 
 
 
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Resolve molecular structures in situ

 
 
 
 
 
 
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Structure and function of complex molecular machines

 
 
 
 
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Host-pathogen interactions

 
 
 
 
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Methods development-

Correlated super-resolution light and electron microscopy

 
 
 
 
 
 
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It is very easy to answer many ... fundamental biological questions; you just look at the thing!
— Richard Feynman (1918-1988)