Chang lab @ Penn

Welcome to

CHANG LAB

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RESEARCH INTERESTS

The structure of macromolecules determines function. The Chang lab is deeply interested in understanding the basics of biology from a structural perspective. Distinct from most of the other structural biology groups working with purified macromolecules, the Chang lab utilizes cryo-electron tomography (cryo-ET), an emerging powerful cryo-electron microscopy imaging technique, to study the structure and mechanism of macromolecular nanomachines directly inside cells. In the native cellular environment, cryo-ET reveals not only native conformations and assemblies of the nanomachines as they are conducting functions, but also their distribution, orientations and interactions to other cellular components – thus uniquely enables studies of structural cell biology and molecular sociology.  

 
 
 
 
 
 
 

Structural cell biology through cryo-electron tomography

 
 
 
 
 
 
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Resolve molecular structures in situ

 
 
 
 
 
 
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Structure and function of complex molecular machines

 
 
 
 
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Host-pathogen interactions

 
 
 
 
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Methods development-

Correlated super-resolution light and electron microscopy

 
 
 
 
 
 
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It is very easy to answer many ... fundamental biological questions; you just look at the thing!
— Richard Feynman (1918-1988)