Chang lab @ Penn


In vivo structures of the Helicobacter pylori cag type IV secretion system

Yi-Wei Chang*, Carrie L Shaffer*, Lee A Rettberg, Debnath Ghosal, Grant J Jensen

Cell Reports 23 (3), 673-681


Molecular architecture of the Legionella Dot/Icm type IV secretion system

Debnath Ghosal, Yi-Wei Chang, Kwangcheol C Jeong, Joseph P Vogel, Grant J Jensen

bioRxiv, 312009


Architecture of the Vibrio cholerae toxin-coregulated pilus machine revealed by electron cryotomography

Yi-Wei Chang, Andreas Kjær, Davi R Ortega, Gabriela Kovacikova, John A Sutherland, Lee A Rettberg, Ronald K Taylor, Grant J Jensen

Nature Microbiology 2 (4), 16269


Morphology of the archaellar motor and associated cytoplasmic cone in Thermococcus kodakaraensis

Ariane Briegel, Catherine M Oikonomou, Yi-Wei Chang, Andreas Kjær, Audrey N Huang, Ki Woo Kim, Debnath Ghosal, Hong H Nguyen, Dorothy Kenny, Rachel R Ogorzalek Loo, Robert P Gunsalus, Grant J Jensen

EMBO Reports 18 (9), 1660-1670


Polar delivery of Legionella type IV secretion system substrates is essential for virulence

Kwangcheol C Jeong, Debnath Ghosal, Yi-Wei Chang, Grant J Jensen, Joseph P Vogel

Proceedings of the National Academy of Sciences 114 (30), 8077-8082


Uncharacterized bacterial structures revealed by electron cryotomography

Megan J Dobro, Catherine M Oikonomou, Aidan Piper, John Cohen, Kylie Guo, Taylor Jensen, Jahan Tadayon, Joseph Donermeyer, Yeram Park, Benjamin A Solis, Andreas Kjær, Andrew I Jewett, Alasdair W McDowall, Songye Chen, Yi-Wei Chang, Jian Shi, Poorna Subramanian, Cristina V Iancu, Zhuo Li, Ariane Briegel, Elitza I Tocheva, Martin Pilhofer, Grant J Jensen

Journal of Bacteriology, JB. 00100-17


In vivo structures of an intact type VI secretion system revealed by electron cryotomography

Yi‐Wei Chang, Lee A Rettberg, Davi R Ortega, Grant J Jensen

EMBO Reports, e201744072


In situ structure of the Legionella Dot/Icm type IV secretion system by electron cryotomography

Debnath Ghosal, Yi‐Wei Chang, Kwangcheol C Jeong, Joseph P Vogel, Grant J Jensen

EMBO Reports 18 (5), 726-732


Short FtsZ filaments can drive asymmetric cell envelope constriction at the onset of bacterial cytokinesis

Qing Yao, Andrew I Jewett, Yi‐Wei Chang, Catherine M Oikonomou, Morgan Beeby, Cristina V Iancu, Ariane Briegel, Debnath Ghosal, Grant J Jensen

The EMBO Journal, e201696235


Dynamics of the peptidoglycan biosynthetic machinery in the stalked budding bacterium Hyphomonas neptunium

Emöke Cserti, Sabine Rosskopf, Yi‐Wei Chang, Sabrina Eisheuer, Lars Selter, Jian Shi, Christina Regh, Ulrich Koert, Grant J Jensen, Martin Thanbichler

Molecular Microbiology 103 (5), 875-895


Architecture of the type IVa pilus machine

Yi-Wei Chang, Lee A Rettberg, Anke Treuner-Lange, Janet Iwasa, Lotte Søgaard-Andersen, Grant J Jensen

Science 351 (6278), aad2001


A new view into prokaryotic cell biology from electron cryotomography

Catherine Oikonomou, Yi-Wei Chang, Grant Jensen

Nature Review Microbiology 14, 205-220


Electron cryotomography

Catherine M Oikonomou, Matthew T Swulius, Ariane Briegel, Morgan Beeby, Qing Yao, Yi-Wei Chang, Grant J Jensen

Methods in Microbiology 43, 115-139


De novo visual proteomics in single cells through pattern mining

Min Xu, Elitza I Tocheva, Yi-Wei Chang, Grant J Jensen, Frank Alber

arXiv preprint arXiv:1512.09347


Correlated cryogenic photoactivated localization microscopy and cryo-electron tomography

Yi-Wei Chang, Songye Chen, Elitza I Tocheva, Anke Treuner-Lange, Stephanie Löbach, Lotte Søgaard-Andersen, Grant J Jensen

Nature Methods 11 (7), 737


Structure of bacterial cytoplasmic chemoreceptor arrays and implications for chemotactic signaling

Ariane Briegel, Mark S Ladinsky, Catherine Oikonomou, Christopher W Jones, Michael J Harris, Daniel J Fowler, Yi-Wei Chang, Lynmarie K Thompson, Judith P Armitage, Grant J Jensen

Elife 3, e02151


Structural basis of a physical blockage mechanism for the interaction of response regulator PmrA with connector protein PmrD from Klebsiella pneumoniae

Shih-Chi Luo, Yuan-Chao Lou, Mahalingam Rajasekaran, Yi-Wei Chang, Chwan-Deng Hsiao, Chinpan Chen

Journal of Biological Chemistry 288 (35), 25551-25561


Crystal Structure of DnaK Protein Complexed with Nucleotide Exchange Factor GrpE in DnaK Chaperone System INSIGHT INTO INTERMOLECULAR COMMUNICATION

Ching-Chung Wu, Vankadari Naveen, Chin-Hsiang Chien, Yi-Wei Chang, Chwan-Deng Hsiao

Journal of Biological Chemistry 287 (25), 21461-21470


Interaction surface and topology of Get3-Get4-Get5 protein complex, involved in targeting tail-anchored proteins to endoplasmic reticulum

Yi-Wei Chang*, Tai-Wen Lin*, Yi-Chuan Li, Yu-Shan Huang, Yuh-Ju Sun, Chwan-Deng Hsiao

Journal of Biological Chemistry 287 (7), 4783-4789


Structural fold, conservation and Fe (II) binding of the intracellular domain of prokaryote FeoB

Kuo-Wei Hung*, Yi-Wei Chang*, Edward T Eng*, Jai-Hui Chen, Yi-Chung Chen, Yuh-Ju Sun, Chwan-Deng Hsiao, Gang Dong, Krasimir A Spasov, Vinzenz M Unger, Tai-huang Huang

Journal of Structural Biology 170 (3), 501-512


Crystal structure of Get4-Get5 complex and its interactions with Sgt2, Get3, and Ydj1

Yi-Wei Chang*, Yu-Chien Chuang*, Yu-Chi Ho, Ming-Yuan Cheng, Yuh-Ju Sun, Chwan-Deng Hsiao, Chung Wang

Journal of Biological Chemistry 285 (13), 9962-9970


Crystal structure of the N-terminal domain of Geobacillus kaustophilus HTA426 DnaD protein

Cheng-Yang Huang, Yi-Wei Chang, Wei-Ti Chen

Biochemical and Biophysical Research Communications 375 (2), 220-224


Crystal structures of the 70-kDa heat shock proteins in domain disjoining conformation

Yi-Wei Chang, Yuh-Ju Sun, Chung Wang, Chwan-Deng Hsiao

Journal of Biological Chemistry 283 (22), 15502-15511


Structure of the SARS coronavirus nucleocapsid protein RNA-binding dimerization domain suggests a mechanism for helical packaging of viral RNA

Chun-Yuan Chen, Chung-ke Chang, Yi-Wei Chang, Shih-Che Sue, Hsin-I Bai, Lilianty Riang, Chwan-Deng Hsiao, Tai-huang Huang

Journal of Molecular Biology 368 (4), 1075-1086